From: Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy
Cancer type | Expression | Effects | Ref. |
---|---|---|---|
Breast cancer | High expression in the TIMER 2.0 and CPTAC databases | Promotes mitochondrial metabolism, aerobic glycolysis, lactate metabolism, metastasis, and apoptosis | |
Lung cancer | High expression in lung stem cells | Promotes glycolysis, metastasis, and tumorigenesis | |
Hepatocellular carcinoma | High expression | Promotes glycolysis, growth and metastasis | |
Glioma | High expression in TIMER 2.0 | Promotes glycolysis, progression, invasion and metastasis | |
Pancreatic adenocarcinoma | Low expression | Promotes metastasis and proliferation | |
Ovarian cancer | High expression | Promotes metastasis and angiogenesis | |
Colorectal cancer | High expression | Promotes invasion, metastasis, and angiogenesis | |
Esophageal squamous cancer | High expression in TIMER 2.0 and significantly higher in metastatic tumor tissues | Promotes metastasis, proliferation, and angiogenesis | |
Osteosarcoma | - | Promotes progression and migration | [112] |
Skin cancer | High expression | Promotes invasion and metastasis |