From: Role of HOXA1-4 in the development of genetic and malignant diseases
ncRNA | Tumor | HOXAs | Direct/Indirect | HOXA up/low expression | Function | References |
---|---|---|---|---|---|---|
miRNAs | ||||||
miR-10a-5p | OC | HOXA1 | Direct | Up | Viability, colony formation, migration ability, invasiveness | [67] |
miR-10b | CC | HOXA1 | Direct | Up | Proliferation, invasion | [68] |
miR-10b | ccRCC | HOXA3 | Direct | Up | Invasion, migration | [69] |
miR-100 | NSCLC | HOXA1 | Direct | Up | Invasion, migration | [70] |
miR-100 | NPC | HOXA1 | Direct | Up | Proliferation | [71] |
miR-202-3p | HCC | HOXA1 | Indirect | Up | Viability, migration, invasion | [64] |
miR-218 | HCC | HOXA1 | Direct | Up | Proliferation | [62] |
miR-218 | MDS | HOXA1 | Direct | Up | Proliferation, colony formation, and apoptosis | [72] |
miR‑338‑3p | T‑LBL | HOXA3 | Direct | Up | Malignancy | [73] |
miR‑577 | NSCLC | HOXA1 | Direct | Up | Proliferation, invasion | [74] |
miR-99a | HCC | HOXA1 | Direct | Up | Invasion, migration | [63] |
miR-99a | OC | HOXA1 | Direct | Up | Proliferation,invasion | [75] |
lncRNAs | ||||||
DLX6‐AS1 | TC | HOXA1 | Direct as a sponge of miR‐193b‐3p | Up | Autophagy, apoptosis | [76] |
HOTAIR | SCLC | HOXA1 | Indirect By H3K27me3 | N/A DNA methylation | Multidrug resistance | [77] |
HOTAIRM1 | GBM | HOXA1 | Demethylation of histone H3K9 and H3K27 | Up | Proliferation, migration, invasion | [78] |
HOTAIRM1 | EC | HOXA1 | N/A | Up | Proliferation, migration, invasion | [79] |
HOXA-AS2 | HB | HOXA3 | Form RNA‐RNA dimers and increase the stability of HOXA3 | Up | Proliferation, migration, invasion | [65] |
HOXA-AS3 | NSCLC | HOXA3 | Direct | Down | EMT, cisplatin resistance | [80] |
LINC00152 | CC | HOXA1 | Direct as a sponge of miR-216b-5p | Up | Proliferation | [81] |
LINC00689 | GC | HOXA3 | Direct as a sponge of miR-338-3p | Up | Cell growth, EMT | [82] |
LINC00958 | LUAD | HOXA1 | N/A | Up | Proliferation, migration | [83] |
SNHG1 | BC | HOXA1 | Direct as a sponge of miR-193a-5p | Up | Proliferation, migration | [84] |
ZFPM2-AS1 | RB | HOXA1 | Direct as a sponge of miR‐515 | Up | Growth, metastasis | [85] |
circRNAs | ||||||
circ_0058063 | Esophageal cancer | HOXA1 | Direct as a sponge of miR-377-3p | Up | Proliferation, migration, invasion, | [86] |
circ_0074032 | PCa | HOXA1 | Direct as a sponge of miR-198 | Up | Proliferation, migration, invasion | [87] |
circ_0008945 | BC | HOXA3 | Direct as a sponge of miR-338-3p | Up | Proliferation, migration, invasion | [88] |
circEIF4G2 | CC | HOXA1 | Direct as a sponge of miR‑218 | Up | proliferation, migration, invasion | [89] |
circRASSF2 | BC | HOXA1 | Direct as a sponge of miR-1205 | Up | Proliferation, migration | [90] |
circWHSC1 | HCC | HOXA1 | Direct as a sponge of miR-142-3p | Up | Proliferation, migration | [66] |