From: MiRNAs as potential therapeutic targets and biomarkers for non-traumatic intracerebral hemorrhage
Neurovascular unit | MiRNA | Targets | Important find | References |
---|---|---|---|---|
OPCs | MiR-3074-3p | Cav-1 | Great clinical value in ischemic demyelination. Ameliorates OPCs clustering and promotes oligodendrogenesis | [4] |
Microglia | MiR-195 | CX3CL1/CX3CR1 signaling pathway | Regulates of microglia M1 polarization | [5] |
OPCs | MiR-23a-5p | Olig3 | Promotes white matter remodeling and repair in stroke and demyelinating diseases | [6] |
ECs | MiR‐140‐5p | VEGFA | Promotes proliferation, migration, and tube formation | [7] |
ECs | Mir‐126‐3p and miR‐126‐5p | IL‐1β, TNF‐α, VCAM‐1, E‐selectin | Maintenances of BBB integrity | [8] |
ECs | MiR‐107 | Dicer‐1 | Promotes angiogenesis | |
MiR‐24‐1‐5p | HIF‐1α | |||
MiR‐191 | NF‐kβ | |||
VSMCs | MiR-552 | ATF4 and SKI | Critical role in the proliferation and migration | [12] |
VSMCs | MiR-137 | Calcineurin/NFATC3 signaling pathway | Modulates the dedifferentiation and proliferation | [13] |
Pericytes | Let-7d | bFGF | Induces of pericyte differentiation | [14] |
Astrocytes | MiR-182-5p | IL-1β, IL-6 and TNF-α | Inhibits neuroinflammation and improves brain injury after ischemic stroke | [15] |
Neurons | MiR‐106b‐5p | Mcl‐1/Bcl‐2 signaling pathway | Inhibits of apoptosis and oxidative stress | [16] |
Neurons | MiR‐149‐5p | P53/caspase‐3 signaling pathway | Regulates of cell survival and apoptosis | [17] |
Neurons and astrocytes | MiR‐19a‐3p | ADIPOR2 | Modulates of glucose metabolism and neuronal apoptosis | [18] |