Table 4 Human studies CAR M-based cells
From: The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors
NCT number | Tumors | Phase | Macrophage source | Study type | Gene transfer | Initial year |
|---|---|---|---|---|---|---|
03608618 | Advanced ovarian and peritoneal mesothelioma | I | PBMCs | Clinical trial | mRNA transfection | 2018 |
04660929 | HER2 overexpression solid tumors | I | Primary human macrophages | Clinical trial | Adenovirus transfection | 2020 |
05007379 | Against organoids from early and advanced breast cancer patients | I | N/A | Cohort | N/A | 2021 |
05138458 | Refractory/ relapsed T-cell lymphoma | I/II | MT-101 (Gathered from PBMCs) | Clinical trial | mRNA transfection | 2021 |