Fig. 3
From: The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors
The CAR M cell functions. Above: The CAR M cells can recognize the tumor cells with TAA-CAR interaction and have various reactions such as secretion of different pro-inflammatory cytokines, induction phagocytosis, and help to remodel tumor ECM by MMPs. Below: The CAR M cells, after activation, can promote the other compartments of the immune system like TAMs, DCs, Ts, and NK cells by different methods to increase the anti-tumor function