From: Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm
Source of Exosomes | Specific Disease Treated | Target/Pathway | Reference |
---|---|---|---|
human umbilical cord MSCs | liver fibrosis | TGF-β1/Smad2 | [30] |
HuES9.E1 MSC | hepatoprotective effects | Cyclin D1, Bcl-xL, STAT3 | [31] |
adipose derived-MSCs | hepatitis | TNF-α, IFN-γ, IL-6, IL-18 and IL-1β | [33] |
human umbilical cord-derived MSCs | renal Ischemia-reperfusion injury (IRI) | VEGF | [34] |
adipose tissue-derived autologous MSCs | renal artery stenosis | TNF-α, IL-6, IL10 and IL-1-β | [35] |
human bone marrow MSCs | acute kidney injury | mRNAs | [36] |
bone marrow MSCs | acute renal injury | Bcl-xL,Bcl2, BIRC8,Casp1, Casp8 and LTA | [37] |
human umbilical cord MSCs | unilateral renal ischemia | lipocalin | [38] |
bone marrow MSCs | acute kidney injury | mRNAs | [36] |
Human bone marrow MSCs | damaged renal tubular | IGF-1R | [39] |
adipose-derived MSC | myocardial ischemia-reperfusion injury | Wnt/β-catenin | [41] |
endometrium-derived MSCs | myocardial infarction | miR-21, PTEN | [42] |
HuES9.E1 derived MSCs | myocardial ischemia/reperfusion injury | PI3K/Akt | [43] |
mouse bone marrow-derived MSCs | myocardial infarction | miR-22, Mecp2 | [44] |
bone marrow MSCs | myocardial infarction | miR-125b | [45] |
human mesenchymal stem cell | cardiac contractility | miR-21-5p, PI3K | [46] |
bone marrow-derived MSCs | myocardial ischaemia reperfusion injury | AMPK/mTOR, Akt/mTOR | [47] |
rat bone marrow derived MSCs | stroke | miR-17-92, PTEN | [50] |
human adipose tissue-derived MSCs | Alzheimer’s disease | neprilysin | [51] |
adipose-derived stem cells | oxygen-glucose deprivation | MicroRNA-181b/TRPM7 | [52] |
mouse bone marrow MSCs | Alzheimer’s disease | STAT3, NF-κB | [53] |
bone marrow derived MSCs | chronic graft-versus-host disease | Treg, Th17 | [55] |
human multipotent stromal cells | type 1 diabetes, uveoretinitis | Th1, Th17 | [56] |
human bone-marrow derived MSCs | asthma | IL-10, TGF-β1 | [57] |
human umbilical cord MSCs | inflammation | MiR-181c, TLR4 | [58] |